Protective role of apigenin in cisplatin-induced renal injury.

@article{He2016ProtectiveRO,
  title={Protective role of apigenin in cisplatin-induced renal injury.},
  author={Xuexiu He and Chunmei Li and Zhengkai Wei and Jingjing Wang and Jinhua Kou and Weijian Liu and Mingyu Shi and Zhengtao Yang and Yunhe Fu},
  journal={European journal of pharmacology},
  year={2016},
  volume={789},
  pages={
          215-221
        }
}

Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

It is suggested that daidzein attenuated cisplatin-induced kidney injury through the downregulation of oxidative/nitrative stress, immune cells, inflammatory cytokines, and apoptotic cell death, thus improving kidney regeneration.

Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro

ApI pretreatment can protect renal function against I/R injury and prevent renal tubular cells from apoptosis in vivo and in vitro which might through PI3K/Akt mediated mitochondria-dependent apoptosis signaling pathway.

Protective effect of urolithin a on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress.

  • Taile JingJiezhi Liao Hao Pan
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2019

Apigenin alleviates methotrexate-induced liver and kidney injury in mice

It is suggested that API has a protective effect against oxidative stress and liver-kidney toxicity induced by MTX, and alleviates liver and kidney toxicity by attenuating oxidative Stress and tissue injury markers, histopathological alterations, and apoptosis and inflammation.

Apigenin Protects Against Renal Tubular Epithelial Cell Injury and Oxidative Stress by High Glucose via Regulation of NF-E2-Related Factor 2 (Nrf2) Pathway

Apigenin protects renal tubular epithelial cells against high glucose-induced injury through suppression of oxidative stress and inflammation via activation of the Nrf2 pathway.

DHA-PC protects kidneys against cisplatin-induced toxicity and its underlying mechanisms in mice.

Investigation of whether DHA-PC treatment could alleviate cisplatin-induced nephrotoxicity using a Balb/c mice model showed that Dha-PC could significantly prolong the survival time, while the traditional DHA had no remarkable changes, suggesting that D HA-PC might be a new dietary strategy for the treatment of neph rotoxicity.

The potential protective role of apigenin against oxidative damage induced by nickel oxide nanoparticles in liver and kidney of male Wistar rat, Rattus norvegicus

Apigenin (APG) can ameliorate the NiONP-induced hepatotoxicity and nephrotoxicity in male Wistar rats and substantially alleviated all the studied parameters.

Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway.

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