Protective role of anti-synthetic hinge peptide antibody for glomerular deposition of hypoglycosylated IgA1

@article{Hiki2007ProtectiveRO,
  title={Protective role of anti-synthetic hinge peptide antibody for glomerular deposition of hypoglycosylated IgA1},
  author={Yoshiyuki Hiki and Kazuo Takahashi and Sachiko Shimozato and Hiroko Odani and Kouichirou Yamamoto and M Tomita and Midori Hasegawa and Kazutaka Murakami and Kunihiro Nabeshima and Shigeru Nakai and Yoshiroh Fujita and Isao Ishida and Hitoo Iwase and Satoshi Sugiyama},
  journal={Clinical and Experimental Nephrology},
  year={2007},
  volume={12},
  pages={20-27}
}
BackgroundThe KM mouse lacks endogenous genes for immunoglobulins and carries the entire human IgH locus and the IgLk transgene. Therefore, human IgA1 does not provoke a hetero-immune response. We had observed mesangial IgA deposits in KM mice given desialo-degalacto (DeS/DeGal) IgA1.Methods In this study, the mice were immunized with synthetic IgA1 hinge (glyco-)peptide before administration of DeS/DeGal IgA1, and the effects of the pre-immunization were evaluated. Mice were divided into sHP… Expand
O-linked oligosaccharides of the IgA1 hinge region: roles of its aberrant structure in the occurrence and/or progression of IgA nephropathy
  • Y. Hiki
  • Medicine
  • Clinical and Experimental Nephrology
  • 2009
TLDR
The process by which the idea of aberrant O-glycosylation in IgA1 molecules in IgAN patients is developed is focused on and an excellent review on the structure and the role of the carbohydrate in Ig a molecules was recently published. Expand
Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation.
TLDR
Low-affinity innate-like IgA, formed in the absence of normal antigen-driven maturation, was more readily involved in IgA glomerular deposition with pathogenic effects, and hinge hypoglycosylation was not mandatory for IgA deposition. Expand
History of IgA Nephropathy Mouse Models
TLDR
All murine IgAN models developed since 1968 are reviewed and their remarkable contribution to understanding the disease is discussed. Expand
Prospects and perspectives on IgA nephropathy from animal models.
TLDR
A systematic and critical review of the insights that experimental models have contributed to the understanding of IgA nephropathy (IgAN) and a synopsis of spontaneous models that do not offer particular mechanistic insights are reviewed. Expand
3. Abnormarity in IgA

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