Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.

@article{Meshkibaf2016ProtectiveRO,
  title={Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.},
  author={Shahab Meshkibaf and Andrew J. Martins and Garth T Henry and Sung Ouk Kim},
  journal={Cytokine},
  year={2016},
  volume={78},
  pages={
          69-78
        }
}
Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine best known for its role in promoting the generation and function of neutrophils. G-CSF is also found to be involved in macrophage generation and immune regulation; however, its in vivo role in immune homeostasis is largely unknown. Here, we examined the role of G-CSF in dextran sulfate sodium (DSS)-induced acute colitis using G-CSF receptor-deficient (G-CSFR(-/-)) mice. Mice were administered with 1.5% DSS in drinking water… CONTINUE READING

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