Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells.

@article{Yokozawa2005ProtectiveRO,
  title={Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells.},
  author={Takako Yokozawa and Akiko Satoh and Eun Ju Cho and Yoshiki Kashiwada and Yasumasa Ikeshiro},
  journal={The Journal of pharmacy and pharmacology},
  year={2005},
  volume={57 3},
  pages={367-74}
}
A study was conducted to elucidate and compare the protective activity of alkaloids from Coptidis Rhizoma (berberine, coptisine, palmatine, epiberberine, jatrorhizine, groenlandicine and magnoflorine) using an LLC-PK(1) cell under peroxynitrite (ONOO(-)) generation model. Treatment with 3-morpholinosydnonimine (SIN-1) led to an increase in cellular ONOO(-) generation in comparison with non-treated cells. However, Coptidis Rhizoma extract and its alkaloids, except for berberine, reduced the… CONTINUE READING
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