Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.

@article{Zernecke2008ProtectiveRO,
  title={Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.},
  author={Alma Zernecke and Ilze Bot and Yassin Djalali-Talab and Erdenechimeg Shagdarsuren and Kiril Bidzhekov and Svenja U Meiler and Regina Krohn and Andreas Schober and Markus Sperandio and Oliver Soehnlein and J{\"o}rg Bornemann and Frank Tacke and Erik A. L. Biessen and Christian Weber},
  journal={Circulation research},
  year={2008},
  volume={102 2},
  pages={
          209-17
        }
}
The CXC ligand (CXCL)12/CXC receptor (CXCR)4 chemokine-receptor axis controls hematopoiesis, organ development, and angiogenesis, but its role in the inflammatory pathogenesis of atherosclerosis is unknown. Here we show that interference with Cxcl12/Cxcr4 by a small-molecule antagonist, genetic Cxcr4 deficiency, or lentiviral transduction with Cxcr4 degrakine in bone marrow chimeras aggravated diet-induced atherosclerosis in apolipoprotein E-deficient (Apoe-/-) or LDL receptor-deficient (Ldlr… CONTINUE READING
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