Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice.

@article{Ohtani2007ProtectiveRO,
  title={Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice.},
  author={M. Ohtani and A. Garc{\'i}a and A. Rogers and Z. Ge and N. Taylor and S. Xu and Koichiro Watanabe and R. Marini and M. Whary and T. Wang and J. Fox},
  journal={Carcinogenesis},
  year={2007},
  volume={28 12},
  pages={
          2597-604
        }
}
The incidence of gastric cancer is higher in men than women. Epidemiological studies suggest that female hormones reduce gastric cancer risk. We examined the effect of ovarian-dependent female hormones on Helicobacter pylori-induced gastric cancer in hypergastrinemic INS-GAS mice. Male and female sexually intact or ovariectomized (OVX) mice were inoculated with H.pylori SS1 or vehicle-only at 10 weeks of age, and tissues were evaluated at 16 or 28 weeks post-infection (WPI). A subset of OVX… Expand
17β-Estradiol and Tamoxifen Prevent Gastric Cancer by Modulating Leukocyte Recruitment and Oncogenic Pathways in Helicobacter Pylori–Infected INS-GAS Male Mice
Localized Suppression of Inflammation at Sites of Helicobacter pylori Colonization
Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice.
Regulation of the Helicobacter pylori Cellular Receptor Decay-accelerating Factor*
Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice.
Helicobacter-based mouse models of digestive system carcinogenesis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific.
...
1
2
3
4
5
...