Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice.

Abstract

The incidence of gastric cancer is higher in men than women. Epidemiological studies suggest that female hormones reduce gastric cancer risk. We examined the effect of ovarian-dependent female hormones on Helicobacter pylori-induced gastric cancer in hypergastrinemic INS-GAS mice. Male and female sexually intact or ovariectomized (OVX) mice were inoculated… (More)

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@article{Ohtani2007ProtectiveRO, title={Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice.}, author={Masahiro Ohtani and Alexis Cordov{\'e}s Garc{\'i}a and Arlin B. Rogers and Zhongming Ge and Nancy S. Taylor and Shilu Xu and Koichiro Watanabe and Robert Marini and Mark T. Whary and Timothy Wang and James G Fox}, journal={Carcinogenesis}, year={2007}, volume={28 12}, pages={2597-604} }