Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

@article{Ngomba2011ProtectiveRF,
  title={Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.},
  author={Richard Teke Ngomba and Ines Santolini and Francesca Biagioni and Gemma Molinaro and Agnes Simonyi and Clementina M. van Rijn and Valerio D'Amore and Federica Mastroiacovo and Giorgia Olivieri and Roberto Gradini and Francesco Ferraguti and Giuseppe Battaglia and Valeria Bruno and Aldamaria Puliti and Gilles L J M van Luijtelaar and Ferdinando Nicoletti},
  journal={Neuropharmacology},
  year={2011},
  volume={60 7-8},
  pages={1281-91}
}
Eight-month old WAG/Rij rats, which developed spontaneous occurring absence seizures, showed a reduced function of mGlu1 metabotropic glutamate receptors in the thalamus, as assessed by in vivo measurements of DHPG-stimulated polyphosphoinositide hydrolysis, in the presence of the mGlu5 antagonist MPEP as compared to age-matched non-epileptic control rats. These symptomatic 8-month old WAG/Rij rats also showed lower levels of thalamic mGlu1α receptors than age-matched controls and 2-month old… CONTINUE READING

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