Protective role for c-Jun in the cellular response to DNA damage.

@article{Potapova2001ProtectiveRF,
  title={Protective role for c-Jun in the cellular response to DNA damage.},
  author={Olga Potapova and Subhendu Basu and Dan Mercola and Nikki J. Holbrook},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 30},
  pages={
          28546-53
        }
}
c-Jun, a member of the activation protein 1 (AP-1) family of transcription factors, has been implicated in the regulation of many important biological processes including cell cycle progression, transformation, differentiation, and apoptosis. Accordingly, its expression and function are upregulated in response to diverse stimuli including mitogens and a wide range of stresses. Transcriptional activation of the c-Jun protein is dependent on its phosphorylation at Ser-63 and Ser-73, a process… CONTINUE READING
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