Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand.

@article{Glinka2006ProtectiveRT,
  title={Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand.},
  author={Yelena Glinka and Yigang Chang and Gerald Joseph Prud'homme},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2006},
  volume={14 4},
  pages={578-87}
}
DNA vaccination of autoimmune diabetes-prone NOD mice with unmodified target islet antigens, i.e., preproinsulin (PPIns) or glutamic acid decarboxylase 65 (GAD65), is poorly protective. However, in this study, we demonstrate protection against disease by covaccination with a mutant B7-1 molecule (B7-1wa) that binds the negative T cell regulator CTLA-4… CONTINUE READING