Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury.

@article{Hoegl2011ProtectivePO,
  title={Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury.},
  author={Sandra Hoegl and Malte Bachmann and Patrick Scheiermann and Itamar Goren and Christian Hofstetter and Josef Pfeilschifter and Bernhard Zwissler and Heiko Muhl},
  journal={American journal of respiratory cell and molecular biology},
  year={2011},
  volume={44 3},
  pages={369-76}
}
High-pressure ventilation induces barotrauma and pulmonary inflammation, thus leading to ventilator-induced lung injury (VILI). IL-22 has both immunoregulatory and tissue-protective properties. Functional IL-22 receptor expression is restricted to nonleukocytic cells, such as alveolar epithelial cells. When applied via inhalation, IL-22 reaches the pulmonary system directly and in high concentrations, and may protect alveolar epithelial cells against cellular stress and biotrauma associated… CONTINUE READING
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