Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

@inproceedings{Shelkovnikova2018ProtectivePH,
  title={Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis},
  author={Tatyana A Shelkovnikova and Michail S. Kukharsky and Haiyan An and Pasquale Dimasi and Svetlana Alexeeva and Osman Shabir and Paul R Heath and Vladimir L Buchman},
  booktitle={Molecular Neurodegeneration},
  year={2018}
}
Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms are unknown. The majority of ALS cases are characterized by TDP-43 proteinopathy. In current study we aimed to establish whether and how TDP-43 pathology may augment paraspeckle assembly. Paraspeckle formation in human samples was analysed by RNA-FISH and laser capture… CONTINUE READING
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