Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies.

@article{Liu2008ProtectiveMO,
  title={Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies.},
  author={H. Liu and Keiko T. Kitazato and Masaaki Uno and Kenji Yagi and Yasuhisa Kanematsu and Tetsuya Tamura and Yoshiteru Tada and Tomoya Kinouchi and Shinji Nagahiro},
  journal={Journal of hypertension},
  year={2008},
  volume={26 7},
  pages={1435-45}
}
BACKGROUND Angiotensin II type 1 (AT1) receptor blockers decrease ischemia by mechanisms dependent on and independent of arterial blood pressure in hypertensive rats and AT1-R knockout mice, respectively. However, the detailed mechanisms underlying the effects of AT1 receptor blockers remain unclear. AIMS To elucidate the systemic and focal effects of AT1 receptor blockers against cerebral ischemia in in-vivo and in-vitro studies. METHODS Normotensive Wistar rats were treated for 2 weeks… CONTINUE READING

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Reversible middle

EZ Longa, PR Weinstein, S Carlson, R. Cummins
Methods Mol Med • 2006

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