Protective mechanisms of resveratrol against methotrexate‐induced renal damage may involve BCRP/ABCG2

@article{ElSheikh2016ProtectiveMO,
  title={Protective mechanisms of resveratrol against methotrexate‐induced renal damage may involve BCRP/ABCG2},
  author={Azza A K El-Sheikh and Mohamed A. Morsy and Abdulla Y. Al-Taher},
  journal={Fundamental \& Clinical Pharmacology},
  year={2016},
  volume={30}
}
Resveratrol (RES) is a well‐known polyphenol antioxidant. We have previously shown that testicular protective effect of RES against the anticancer drug methotrexate (MTX)‐induced toxicity involves transporter‐mediated mechanisms. Here, we investigated the effect of RES on MTX‐induced nephrotoxicity. Rats were administered RES (10 mg/kg/day) for 8 days, with or without a single MTX dose (20 mg/kg i.p.) at day 4 of the experiment. MTX induced nephrotoxicity, as evidenced by a significant increase… Expand
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