Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.

Abstract

Certain MHC-II or HLA-D alleles dominantly protect from particular autoimmune diseases. For example, expression of the MHC-II Eα:Eβ complex potently protects nonobese diabetic (NOD) mice, which normally lack this isotype, from spontaneous development of type 1 diabetes. However, the underlying mechanisms remain debated. We investigated MHC-II-mediated… (More)
DOI: 10.1073/pnas.1712280114

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@article{Silverman2017ProtectiveMH, title={Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.}, author={Michael Silverman and Lindsay Kua and Alessandro Tanca and Mauro Pala and Antonio Palomba and Ceylan Tanes and Kyle Bittinger and Sergio Uzzau and Christophe Benoist and Diane J. Mathis}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 36}, pages={9671-9676} }