Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves.

@article{Konturek2007ProtectiveIO,
  title={Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves.},
  author={Stanisław Jan Konturek and Oksana Zayachkivska and X O Havryluk and Tomasz Brzozowski and Zbigniew Śliwowski and Mareike Pawlik and Peter C. Konturek and Marta Cześnikiewicz-Guzik and Miechyslav Gzhegotsky and Wieslaw W. Pawlik},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2007},
  volume={58 2},
  pages={361-77}
}
Melatonin (MT) is known to protect gastrointestinal mucosa against various types of injury but its effects on esophageal damage have not been studied. We examined the effects of MT on acute esophageal injury and the mechanism involved in the action of this indole. Acute esophageal lesions were induced by perfusion with acid-pepsin solution using tube inserted through the oral cavity into the mid of esophagus of anaesthetized rats with or without inhibition of prostaglandin (PG) generation by… CONTINUE READING