Protective immunity to liver-stage malaria

  title={Protective immunity to liver-stage malaria},
  author={Lauren Holz and Daniel Fernandez-Ruiz and William R Heath},
  booktitle={Clinical & translational immunology},
Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the liver acts as a bottleneck to blood-stage infection, it represents a potential site for parasite and… CONTINUE READING
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