Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant.

@article{Saito2001ProtectiveIT,
  title={Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant.},
  author={Masayoshi Saito and Shigeo Otake and Mari Ohmura and Masao Hirasawa and Koji Takada and Junichi Mega and Ichiro Takahashi and Hiroshi Kiyono and Jerry R. Mcghee and Yoshifumi Takeda and Masafumi Yamamoto},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={183 5},
  pages={823-6}
}
In this study, mice were immunized nasally with surface protein antigen of Streptococcus mutans serotype c (PAc) and a nontoxic A subunit mutant of cholera toxin (mCT) E112K, as a mucosal adjuvant. Immunization with PAc and mCT elicited significant PAc-specific secretory IgA in saliva and in nasal secretions. Antibody-forming cell (AFC) analysis confirmed the antibody (Ab) titers by revealing significant numbers of PAc-specific IgA AFCs in the submandibular gland and nasal passages. Furthermore… CONTINUE READING
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