Protective immunity of recombinant LipL21 and I-LipL21 against Leptospira interrogans serovar Autumnalis N2 infection.

  title={Protective immunity of recombinant LipL21 and I-LipL21 against Leptospira interrogans serovar Autumnalis N2 infection.},
  author={Anita Kumari and Mallela Martha Premlatha and Veerapandian Raja and Charles Solomon Akino Mercy and K. Sumathi and Malini Shariff and Kalimuthusamy Natarajaseenivasan},
  journal={Journal of infection in developing countries},
  volume={12 1},
INTRODUCTION Leptospirosis is a zoonotic disease caused by the spirochete of genus Leptospira with widespread distribution in tropical, subtropical and temperate zones. Leptospirosis is often confused with other febrile illnesses including jaundice, dengue, and malaria. Generally, the disease is often underdiagnosed or misdiagnosed. Though leptospirosis is curable with antibiotic treatment, the laboratory diagnosis of the disease is specialized and open to interpretation with multiple kits… 
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Research status and perspectives for pathogenic spirochete vaccines.
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The results presented here are the first demonstration that a LipL45 based DNA immunogen has potential as a anti-Leptospira vaccine.
Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine.
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In Vivo-Expressed Proteins of Virulent Leptospira interrogans Serovar Autumnalis N2 Elicit Strong IgM Responses of Value in Conclusive Diagnosis
Nine immunoreactive proteins, ArgC, RecA, GlpF, FliD, TrmD, RplS, RnhB, Lp28.6, and Lrr44.9 were found to be highly conserved among pathogenic leptospires and were effective in laboratory confirmation of Leptospira infection.
Experimental lethal infection of Leptospira interrogans in mice treated with cyclophosphamide.
The results indicated that cyclophosphamide-treated mice can be used in the experimental infection of Leptospira in place of hamsters or guinea pigs.
Immunoprotection of Recombinant Leptospiral Immunoglobulin-Like Protein A against Leptospira interrogans Serovar Pomona Infection
Results from this study indicate that rLigA is a potential vaccine candidate against L. interrogans serovar Pomona infection.
A Leptospira borgpetersenii Serovar Hardjo Vaccine Induces a Th1 Response, Activates NK Cells, and Reduces Renal Colonization
Compared two monovalent killed bacterial cell vaccines were compared to assess long-term protection against live serovar Hardjo challenge and it was proposed that programming NK cells to respond quickly to L. borgpetersenii serovAR Hardjo infection may be an important step toward developing protective immunity.
Leptospirosis: a zoonotic disease of global importance.
The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease.
Outbreak of leptospirosis with pulmonary involvement in north Andaman.
Clinical and epidemiological observations of this outbreak were similar with that of earlier seasonal outbreaks of acute febrile illness with haemorrhagic manifestations occurring in the same area, indicating that the past outbreaks may also have been due to leptospires.
Immunogenicity and protective efficacy of recombinant Leptospira immunoglobulin-like protein B (rLigB) in a hamster challenge model.
It is shown that LigB has emerged as novel protective antigen that can be used in future subunit vaccines against leptospirosis and concurrent administration of all three fragments significantly enhanced the protective efficacy of the vaccine.
OmpL1 Is an Extracellular Matrix- and Plasminogen-Interacting Protein of Leptospira spp
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