Protective immunity of recombinant LipL21 and I-LipL21 against Leptospira interrogans serovar Autumnalis N2 infection.

@article{Kumari2018ProtectiveIO,
  title={Protective immunity of recombinant LipL21 and I-LipL21 against Leptospira interrogans serovar Autumnalis N2 infection.},
  author={Anita Kumari and Mallela Martha Premlatha and Veerapandian Raja and Charles Solomon Akino Mercy and K. Sumathi and Malini Shariff and Kalimuthusamy Natarajaseenivasan},
  journal={Journal of infection in developing countries},
  year={2018},
  volume={12 1},
  pages={
          22-30
        }
}
INTRODUCTION Leptospirosis is a zoonotic disease caused by the spirochete of genus Leptospira with widespread distribution in tropical, subtropical and temperate zones. Leptospirosis is often confused with other febrile illnesses including jaundice, dengue, and malaria. Generally, the disease is often underdiagnosed or misdiagnosed. Though leptospirosis is curable with antibiotic treatment, the laboratory diagnosis of the disease is specialized and open to interpretation with multiple kits… 
1 Citations
Research status and perspectives for pathogenic spirochete vaccines.
TLDR
The development of relevant vaccines against pathogenic spirochetes has generally proceeded via several stages, such as the whole-cell inactivated vaccine, live attenuated vaccine, and gene-engineeredvaccine, and will likely enter a new stage with the application of gene editing technology.

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The results presented here are the first demonstration that a LipL45 based DNA immunogen has potential as a anti-Leptospira vaccine.
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