Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma.

@article{Sun2003ProtectiveII,
  title={Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma.},
  author={Peifang Sun and Robert Schwenk and Katherine White and Jose Antonio Stoute and Joe Cohen and William Ripley Ballou and G. S. Voss and Kent E. Kester and Donald G Heppner and Urszula Krzych},
  journal={Journal of immunology},
  year={2003},
  volume={171 12},
  pages={6961-7}
}
The Plasmodium falciparum circumsporozoite (CS) protein-based pre-erythrocytic stage vaccine, RTS,S, induces a high level of protection against experimental sporozoite challenge. The immune mechanisms that constitute protection are only partially understood, but are presumed to rely on Abs and T cell responses. In the present study we compared CS protein peptide-recalled IFN-gamma reactivity of pre- and RTS,S-immune lymphocytes from 20 subjects vaccinated with RTS,S. We observed elevated IFN… CONTINUE READING

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