Protective immunity induced by rotavirus DNA vaccines.

  title={Protective immunity induced by rotavirus DNA vaccines.},
  author={Suzhen Chen and E F Fynan and Harriet L Robinson and Shan Lu and Harry B Greenberg and Joseph C Santoro and John E. Herrmann},
  volume={15 8},
It is estimated that Group A rotavirus diarrhea causes as many as one million deaths per year in children worldwide, and effective vaccines will be essential for their control. Plasmid DNA vaccines encoding murine rotaviral proteins VP4, VP6, or VP7 were tested in adult BALB/c mice for their ability to induce immune responses and provide protection against rotavirus challenge. The vaccines were administered by inoculation into cells of the epidermis with an Accell gene gun. (Auragen, Inc… CONTINUE READING


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