Protective immunity induced by live attenuated simian immunodeficiency virus.

@article{Johnson1998ProtectiveII,
  title={Protective immunity induced by live attenuated simian immunodeficiency virus.},
  author={R Paul Johnson and Ronald C Desrosiers},
  journal={Current opinion in immunology},
  year={1998},
  volume={10 4},
  pages={436-43}
}
Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing… CONTINUE READING