Protective immunity against infectious spleen and kidney necrosis virus induced by immunization with DNA plasmid containing mcp gene in Chinese perch Siniperca chuatsi.

@article{Fu2014ProtectiveIA,
  title={Protective immunity against infectious spleen and kidney necrosis virus induced by immunization with DNA plasmid containing mcp gene in Chinese perch Siniperca chuatsi.},
  author={Xiaozhe Fu and Ning-qiu Li and Qiang Lin and Huizhi Guo and Defeng Zhang and Lihui Liu and Shu-qin Wu},
  journal={Fish & shellfish immunology},
  year={2014},
  volume={40 1},
  pages={259-66}
}
Infectious spleen and kidney necrosis virus (ISKNV) is the causative agent of a disease leading to high mortality and economic losses in Chinese perch, Siniperca chuatsi. There is an urgent need to develop an effective vaccine against this fatal disease. In this study, the mcp gene encoding the major capsid protein, the predominant structural component of the iridovirus particles, was cloned into a eukaryotic expression vector pcDNA3.1+, and the recombinant plasmid, designated as pcMCP, was… CONTINUE READING
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