Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3

@inproceedings{Zhang2013ProtectiveIA,
  title={Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3},
  author={Nian-Zhang Zhang and Si-Yang Huang and Dong-Hui Zhou and Jiayou Chen and Ying Xu and Wei-Peng Tian and Jing Lu and Xing-Quan Zhu},
  booktitle={BMC Infectious Diseases},
  year={2013}
}
BackgroundToxoplasma gondii can infect almost all warm-blood animals including human beings. The plant-like calcium-dependent protein kinases (CDPKs) harbored by T. gondii are involved in gliding motility, cell invasion, egress and some other developmental processes, and so have been implicated as important virulence factors.MethodsIn the present study, we constructed a DNA vaccine expressing T. gondii CDPK3 (TgCDPK3) and evaluated its protective efficacy against T. gondii infection in Kunming… CONTINUE READING

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