Protective immunity against Helicobacter is characterized by a unique transcriptional signature.

@article{Mller2003ProtectiveIA,
  title={Protective immunity against Helicobacter is characterized by a unique transcriptional signature.},
  author={Anne Dorothee M{\"u}ller and Jani O'rourke and Pauline L. Chu and Charles C. Kim and Philip Sutton and Adrian Drake Lee and Stanley Falkow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 21},
  pages={12289-94}
}
Immunization with a whole-cell sonicate vaccine of Helicobacter felis in conjunction with cholera toxin as a mucosal adjuvant induces long-term protective immunity in a majority of laboratory mice. We have combined gene expression profiling and immunohistochemical analysis on a set of immunized animals to better understand the mechanism of protection. The stomachs of protected animals exhibited a strikingly different transcriptional profile compared with those of nonprotected or control mice… CONTINUE READING
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Immunol

  • P. Sutton, J. Wilson, T. Kosaka, I. Wolowczuk, A. Lee
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