Protective immune responses against West Nile virus are primed by distinct complement activation pathways

@article{Mehlhop2006ProtectiveIR,
  title={Protective immune responses against West Nile virus are primed by distinct complement activation pathways},
  author={Erin Mehlhop and Michael S Diamond},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={1371 - 1381}
}
West Nile virus (WNV) causes a severe infection of the central nervous system in several vertebrate animals including humans. Prior studies have shown that complement plays a critical role in controlling WNV infection in complement (C) 3(-/-) and complement receptor 1/2(-/-) mice. Here, we dissect the contributions of the individual complement activation pathways to the protection from WNV disease. Genetic deficiencies in C1q, C4, factor B, or factor D all resulted in increased mortality in… CONTINUE READING

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