Protective immune response in mice induced by a suicidal DNA vaccine encoding NTPase-II gene of Toxoplasma gondii.

@article{Zheng2017ProtectiveIR,
  title={Protective immune response in mice induced by a suicidal DNA vaccine encoding NTPase-II gene of Toxoplasma gondii.},
  author={Lina Zheng and Yue Hu and Qianqian Hua and Fangjun Luo and Guizhen Xie and Xiangzhi Li and Jiaxin Lin and Yujing Wan and Shoufeng Ren and Changwang Pan and Feng Tan},
  journal={Acta tropica},
  year={2017},
  volume={166},
  pages={
          336-342
        }
}
DNA-based alphaviral RNA replicon vectors, also called suicidal DNA vectors, have been employed to alleviate biosafety concerns attribution to its ability to induce apoptotic cell death of the transfected cells. Toxoplasma gondii nucleoside triphosphate hydrolase-II (TgNTPase-II), which facilitates the parasite to salvage purines from the host cell for survival and replication, have been demonstrated to be a potential vaccine candidate for toxoplasmosis. Herein, we evaluated the immunogenic… CONTINUE READING
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