Protective efficacy of recombinant Yersinia outer proteins against bubonic plague caused by encapsulated and nonencapsulated Yersinia pestis.

@article{Andrews1999ProtectiveEO,
  title={Protective efficacy of recombinant Yersinia outer proteins against bubonic plague caused by encapsulated and nonencapsulated Yersinia pestis.},
  author={Gerard P. Andrews and S T Strachan and G E Benner and A K Sample and Grant D. W. Anderson and Jeffrey J. Adamovicz and Susan L. Welkos and Jeffrey K. Pullen and Arthur M. Friedlander},
  journal={Infection and immunity},
  year={1999},
  volume={67 3},
  pages={1533-7}
}
To evaluate the role of Yersinia outer proteins (Yops) in conferring protective immunity against plague, six yop loci from Yersinia pestis were individually amplified by PCR, cloned, and expressed in Escherichia coli. The recombinant proteins were purified and injected into mice. Most Yop-vaccinated animals succumbed to infection with either wild-type encapsulated Y. pestis or a virulent, nonencapsulated isogenic variant. Vaccination with YpkA significantly prolonged mean survival time but did… CONTINUE READING

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