Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection.

@article{Cotter1995ProtectiveEO,
  title={Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection.},
  author={T W Cotter and Quanxin Meng and Z L Shen and Y. X. Zhang and Hua Su and Harlan D. Caldwell},
  journal={Infection and immunity},
  year={1995},
  volume={63 12},
  pages={4704-14}
}
The protective efficacy of immunoglobulin A (IgA) and IgG monoclonal antibodies (MAbs) specific for the major outer membrane protein of Chlamydia trachomatis MoPn was evaluated in a murine genital tract infection model. MAbs were delivered into serum and vaginal secretions of naive mice by using the backpack hybridoma tumor system, and protective efficacy was assessed over the first 8 days following challenge by quantitative determination of chlamydial recovery from cervicovaginal swabs… CONTINUE READING

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Reassessment of Chlamydia trachomatis transmission by polymerase chain reaction among 460 sexual partners, p. 21–24

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