Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats

@article{Appenroth1997ProtectiveEO,
  title={Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats},
  author={Dorothea Appenroth and S. Fr{\"o}b and Lutz Kersten and F K Splinter and Klaus Winnefeld},
  journal={Archives of Toxicology},
  year={1997},
  volume={71},
  pages={677-683}
}
Abstract The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg α-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The effect of vitamin E on cisplatin (CP; 0.6 mg/100 g body wt., i.p.) nephrotoxicity was investigated by determining urinary volume and protein excretion, as well as the… 

Vitamin E and C in the prevention of metal nephrotoxicity in developing rats.

  • D. AppenrothK. Winnefeld
  • Biology, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 1998

Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study.

Vitamin C is an effective chemoprotective agent against nephrotoxicity induced by the antitumoral cisplatin in Wistar adult rats, using single doses of both compounds.

Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats.

Effects of Vitamin E pretreatment on subacute toxicity of mixture of Co, Pb, and Hg nitrate-induced nephrotoxicity in rats.

Protective Effects of Onion Oil and Selenium against Cisplatin-Induced Nephrotoxicity and Oxidative Stress in Rats

Background: Nephrotoxicity is an inherent of certain anticancer drugs. Aim: This study aimed to assess the protective effect of onion oil and selenium against cisplatin-induced nephrotoxicity in male

Dose-related protecting effects of vitamin C in gentamicin-induced rat nephrotoxicity: a histopathologic and biochemical study

In high-dose animals, normal glomerular and tubular function on recovery from toxic renal failure led us to conclude that antioxidant properties of vitamin C consistently increase with dose intensity.

Protection against cisplatin-induced nephrotoxicity by Spirulina in rats

In vitro studies using human ovarian cancer cells revealed that Spirulina did not interfere with the cytotoxic effects of CP on tumor cells, and protected the rats from CP-induced nephrotoxicity through its antioxidant properties.

Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats.

It is suggested that the natural antioxidants curcumin or selenium did not offer protection against cisplatin-induced nephrotoxicity and lipid peroxidation in adult Wistar rats.
...

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