Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats

  title={Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats},
  author={Dorothea Appenroth and S. Fr{\"o}b and Lutz Kersten and F K Splinter and Klaus Winnefeld},
  journal={Archives of Toxicology},
Abstract The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg α-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The effect of vitamin E on cisplatin (CP; 0.6 mg/100 g body wt., i.p.) nephrotoxicity was investigated by determining urinary volume and protein excretion, as well as the… 

Vitamin E and C in the prevention of metal nephrotoxicity in developing rats.

  • D. AppenrothK. Winnefeld
  • Biology, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 1998

Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study.

Vitamin C is an effective chemoprotective agent against nephrotoxicity induced by the antitumoral cisplatin in Wistar adult rats, using single doses of both compounds.

Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats.

Effects of Vitamin E pretreatment on subacute toxicity of mixture of Co, Pb, and Hg nitrate-induced nephrotoxicity in rats.

Protective Effects of Onion Oil and Selenium against Cisplatin-Induced Nephrotoxicity and Oxidative Stress in Rats

Background: Nephrotoxicity is an inherent of certain anticancer drugs. Aim: This study aimed to assess the protective effect of onion oil and selenium against cisplatin-induced nephrotoxicity in male

Dose-related protecting effects of vitamin C in gentamicin-induced rat nephrotoxicity: a histopathologic and biochemical study

In high-dose animals, normal glomerular and tubular function on recovery from toxic renal failure led us to conclude that antioxidant properties of vitamin C consistently increase with dose intensity.

Protection against cisplatin-induced nephrotoxicity by Spirulina in rats

In vitro studies using human ovarian cancer cells revealed that Spirulina did not interfere with the cytotoxic effects of CP on tumor cells, and protected the rats from CP-induced nephrotoxicity through its antioxidant properties.

Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats.

It is suggested that the natural antioxidants curcumin or selenium did not offer protection against cisplatin-induced nephrotoxicity and lipid peroxidation in adult Wistar rats.



Nephrotoxicity and pharmacokinetics of cisplatinum in young and adult rats.

Experiments on time dependence of nephrotoxicity showed that in young rats symptoms occurred already 6 h afterCP-administration, and 72 h after CP the damage was nearly completely repaired.

Changes in Serum, Liver and Kidneys of Cisplatin-Treated Rats; Effects of Antioxidants

  • E. BoginM. MaromY. Levi
  • Biology
    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies
  • 1994
Administration of cysteine and vitamin E together with cisplatin partially reversed the uraemia and many of the biochemical changes induced by cisPlatin.

Contribution to the mechanism of chromate nephrotoxicity in developing rats: EPR investigations

Lower nephrotoxicity was accompanied by slower disappearance of Cr(VI) from renal tissue homogenate in vitro, and the stabilization of reactive Cr(V) by GSH seemed to be decisive for the preventive effect of BSO and CCNU as well as for age differences in chromate neph rotoxicity.

Combined effects of vitamin E (alpha-tocopherol) and cisplatin on the growth of murine neuroblastoma in vivo.

Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues.

The results suggest that cis platin affects renal tissues in which free radicals generated by cisplatin may interact with membrane lipids to cause the production of lipid peroxidation, which affects both cellular structure and function.

Mechanism of the increase in lipid peroxide induced by cisplatin in the kidneys of rats.

Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats

After the administration of equal doses of sodium dichromate, chromium concentrations in the kidney were lower in young than in adult rats, suggesting age‐dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age.