• Corpus ID: 88059858

Protective effects of total flavonoids of Sarcandra glabra(Thunb.)Nakai on potassium bromate-induced kidney damage in mice

@article{Wenyan2012ProtectiveEO,
  title={Protective effects of total flavonoids of Sarcandra glabra(Thunb.)Nakai on potassium bromate-induced kidney damage in mice},
  author={Wu Wen-yan},
  journal={Strait Pharmaceutical Journal},
  year={2012}
}

• Wu Wen-yan
• Published 2012
• Biology
• Strait Pharmaceutical Journal

OBJECTIVE To investigate the protective effects of total flavonoids of Sarcandra glabra(Thunb.)Nakai(TFS) on potassium bromate(KBrO3)-induced kidney damage in mice.METHODS The kidney damage model was established by receiving a single ip administration of 200mg·kg-1 KBrO3 in mice.Serum creatinine level and the contents of glutathione(GSH) in kidneys were determined by high performance liquid chromatography(HPLC).Spectrophotometric method was performed to detect the levels of malondialdehyde(MDA) and glutathione peroxidase(GSH-PX) activity in kidneys.Griess method was performed to detect nitric oxide(NO) levels in plasma and kidneys.RESULTS Compared with the model group,TFS could effectively decrease serum creatinine level and the contents of MDA in kidneys.NO levels in plasma and kidneys decreased in the same schedule.In contrast,the contents of GSH and GSH-PX in kidneys increased in mice treated with TFS.CONCLUSION Our findings suggested that protective effects of TFS on KBrO3-induced kidney damage related to its free radical scavenging activity and oxidative stress inhibitory effect.