• DOI:10.1016/S0140-6736(02)08273-9
Corpus ID: 37952036

Protective effects of the sickle cell gene against malaria morbidity and mortality

@article{Aidoo2002ProtectiveEO,
  title={Protective effects of the sickle cell gene against malaria morbidity and mortality},
  author={M. Aidoo and D. Terlouw and M. Kolczak and P. Mcelroy and F. Kuile and S. Kariuki and B. Nahlen and A. Lal and V. Udhayakumar},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={1311-1312}
}

• M. Aidoo, D. Terlouw, +6 authors V. Udhayakumar
• Published 2002
• Biology, Medicine
• The Lancet

The high frequency of the sickle-cell haemoglobin (HbS) gene in malaria endemic regions is believed to be due to a heterozygote (HbAS) advantage against fatal malaria. [...] Key Result We show that HbAS provides significant protection against all-cause mortality, severe malarial anaemia, and high-density parasitaemia. This significant reduction in mortality was detected between the ages of 2 and 16 months, the highest risk period for severe malarial anaemia in this area. These data are important in…Expand