Protective effects of the sickle cell gene against malaria morbidity and mortality

  title={Protective effects of the sickle cell gene against malaria morbidity and mortality},
  author={M. Aidoo and D. Terlouw and M. Kolczak and P. Mcelroy and F. Kuile and S. Kariuki and B. Nahlen and A. Lal and V. Udhayakumar},
  journal={The Lancet},
The high frequency of the sickle-cell haemoglobin (HbS) gene in malaria endemic regions is believed to be due to a heterozygote (HbAS) advantage against fatal malaria. [...] Key Result We show that HbAS provides significant protection against all-cause mortality, severe malarial anaemia, and high-density parasitaemia. This significant reduction in mortality was detected between the ages of 2 and 16 months, the highest risk period for severe malarial anaemia in this area. These data are important in…Expand
Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases.
The present data are useful in that they confirm the mechanisms by which HbAS confers protection against malaria and shed light on the relationships between Hbas, malaria, and other childhood diseases. Expand
Association between Sickle Cell Trait and Low Density Parasitaemia in a P. falciparum Malaria Holoendemic Region of Western Kenya
A study looks at the relationship between sickle cell trait, age, haemoglobin level, and malaria parasite density in subSaharan Africa and the Middle East. Expand
A Mathematical Model of Sickle Cell Genome Frequency in Response to Selective Pressure from Malaria
A model incorporating three genotypes and two age cohorts is used to test the hypothesis that higher death rates due to malaria can exert selective pressure to increase the prevalence of the sickle cell gene. Expand
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria. Expand
Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria.
  • N. Contreras, A. Alviz
  • Biology, Medicine
  • Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
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The purpose of this review is to introduce the molecular and biochemical basis of defense mechanisms associated with sickle-cell trait and Glucose-6-phosphate Dehydrogenase Deficiency (G6PD), which is the most frequent enzymopathy present in humans. Expand
Modelling malaria and sickle cell gene
The main aim is to investigate the impact of malaria treatment on the frequency of sickle cell gene, and develops a mathematical model that describes the interactions between malaria and sicklecell gene under malaria treatment. Expand
An Immune Basis for Malaria Protection by the Sickle Cell Trait
Analysis of the age-specific protection afforded by HbAS against clinical malaria in children living on the coast of Kenya found that protection increased with age from only 20% in the first 2 y of life to a maximum of 56% by the age of 10 y, returning thereafter to 30% in participants greater than 10 y old. Expand
Human red blood cell polymorphisms and malaria.
  • T. Williams
  • Biology, Medicine
  • Current opinion in microbiology
  • 2006
Genetic factors are a major determinant of child survival in malaria endemic countries. Identifying which genes are involved and how they affect the malaria disease risk potentially offers a powerfulExpand
Prevalence of fetal hemoglobin and antibody responses to plasmodium falciparum antigens in sickle cell disease patients in Western Kenya
The prevalence and levels of HbF and the IgG responses to Plasmodium falciparum antigens in 100 SCD patients aged 5-30 years living in a malariaendemic area in Western Kenya imply that HBF can provide protection against malaria in SCD Patients living in malaria endemic areas and thus increase their life expectancy. Expand
Differential impact of sickle cell trait on symptomatic and asymptomatic malaria.
A mathematical model of malaria transmission that incorporates the evolutionary dynamics of S-gene frequency indicates that the fitness of sickle cell trait is likely to increase with the proportion of symptomatic malaria infections, and shows that control efforts aimed at diminishing the burden of symptoma malaria are not likely to eradicate malaria in endemic areas. Expand


Common West African HLA antigens are associated with protection from severe malaria
Data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens. Expand
Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children.
Anemia was consistently associated with high density infection in children < 10 years of age (20% to 210% increased risk relative to aparasitemic children) and two clinical manifestations of malarial illness are demonstrated. Expand
All-cause mortality among young children in western Kenya. VI: the Asembo Bay Cohort Project.
The results provide a baseline description of all-cause mortality among children in an area with intense Plasmodium falciparum transmission and will be useful in future efforts to monitor changes in death rates attributable to control programs for specific diseases in Africa. Expand
Analysis of repeated hemoglobin measures in full-term, normal birth weight Kenyan children between birth and four years of age. III. The Asemobo Bay Cohort Project.
This is the first description of an analysis strategy specifically for repeated Hb measures collected in a longitudinal field study in Africa to facilitate improved study of time-varying covariates thought to influence pediatric anemia. Expand
  • A. Allison
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 1964