Protective effects of the sickle cell gene against malaria morbidity and mortality

  title={Protective effects of the sickle cell gene against malaria morbidity and mortality},
  author={Michael Aidoo and Dianne J Terlouw and Margarette S. Kolczak and Peter D. Mcelroy and Feiko O. ter Kuile and Simon Kariuki and Bernard L. Nahlen and Altaf A. Lal and Venkatachalam Udhayakumar},
  journal={The Lancet},
Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases.
The present data are useful in that they confirm the mechanisms by which HbAS confers protection against malaria and shed light on the relationships between Hbas, malaria, and other childhood diseases.
Association between Sickle Cell Trait and Low Density Parasitaemia in a P. falciparum Malaria Holoendemic Region of Western Kenya
A study looks at the relationship between sickle cell trait, age, haemoglobin level, and malaria parasite density in subSaharan Africa and the Middle East.
A Mathematical Model of Sickle Cell Genome Frequency in Response to Selective Pressure from Malaria
A model incorporating three genotypes and two age cohorts is used to test the hypothesis that higher death rates due to malaria can exert selective pressure to increase the prevalence of the sickle cell gene.
Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria.
  • N. Contreras, A. Alviz
  • Biology
    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
  • 2019
Modelling malaria and sickle cell gene
The main aim is to investigate the impact of malaria treatment on the frequency of sickle cell gene, and develops a mathematical model that describes the interactions between malaria and sicklecell gene under malaria treatment.
An Immune Basis for Malaria Protection by the Sickle Cell Trait
Analysis of the age-specific protection afforded by HbAS against clinical malaria in children living on the coast of Kenya found that protection increased with age from only 20% in the first 2 y of life to a maximum of 56% by the age of 10 y, returning thereafter to 30% in participants greater than 10 y old.
Human red blood cell polymorphisms and malaria.
  • T. Williams
  • Biology, Medicine
    Current opinion in microbiology
  • 2006
Differential impact of sickle cell trait on symptomatic and asymptomatic malaria.
A mathematical model of malaria transmission that incorporates the evolutionary dynamics of S-gene frequency indicates that the fitness of sickle cell trait is likely to increase with the proportion of symptomatic malaria infections, and shows that control efforts aimed at diminishing the burden of symptoma malaria are not likely to eradicate malaria in endemic areas.
Sickle Cell Anaemia and Malaria
  • L. Luzzatto
  • Medicine
    Mediterranean journal of hematology and infectious diseases
  • 2012
The close and complex relationship between this blood disease and this infectious disease is focused on, with patients who are homozygous for the sickle gene and therefore suffer from sickle cell anaemia (SCA) highly susceptible to the lethal effects of malaria.
Influence of Sickle Cell Gene on the Allelic Diversity at the msp-1 locus of Plasmodium falciparum in Adult Patients with Severe Malaria
Sickle gene was found to reduce both the parasite densities and diversity of P. falciparum in adults with severe malaria.


Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children.
Anemia was consistently associated with high density infection in children < 10 years of age (20% to 210% increased risk relative to aparasitemic children) and two clinical manifestations of malarial illness are demonstrated.
All-cause mortality among young children in western Kenya. VI: the Asembo Bay Cohort Project.
The results provide a baseline description of all-cause mortality among children in an area with intense Plasmodium falciparum transmission and will be useful in future efforts to monitor changes in death rates attributable to control programs for specific diseases in Africa.
  • A. Allison
  • Biology
    Cold Spring Harbor symposia on quantitative biology
  • 1964
Common West African HLA antigens are associated with protection from severe malaria
Data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.
Analysis of repeated hemoglobin measures in full-term, normal birth weight Kenyan children between birth and four years of age. III. The Asemobo Bay Cohort Project.
This is the first description of an analysis strategy specifically for repeated Hb measures collected in a longitudinal field study in Africa to facilitate improved study of time-varying covariates thought to influence pediatric anemia.