Protective effects of the sickle cell gene against malaria morbidity and mortality

@article{Aidoo2002ProtectiveEO,
  title={Protective effects of the sickle cell gene against malaria morbidity and mortality},
  author={Michael Aidoo and Dianne J Terlouw and Margarette S. Kolczak and Peter D. Mcelroy and Feiko O. ter Kuile and Simon Kariuki and Bernard L. Nahlen and Altaf A. Lal and Venkatachalam Udhayakumar},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={1311-1312}
}
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580 Citations
Highly Influential Citations
20
Background Citations
187
Methods Citations
14
Results Citations
20

580 Citations

Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases.
TLDR
The present data are useful in that they confirm the mechanisms by which HbAS confers protection against malaria and shed light on the relationships between Hbas, malaria, and other childhood diseases.
Association between Sickle Cell Trait and Low Density Parasitaemia in a P. falciparum Malaria Holoendemic Region of Western Kenya
TLDR
A study looks at the relationship between sickle cell trait, age, haemoglobin level, and malaria parasite density in subSaharan Africa and the Middle East.
A Mathematical Model of Sickle Cell Genome Frequency in Response to Selective Pressure from Malaria
TLDR
A model incorporating three genotypes and two age cohorts is used to test the hypothesis that higher death rates due to malaria can exert selective pressure to increase the prevalence of the sickle cell gene.
Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria.
  • N. Contreras, A. Alviz
  • Biology
    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
  • 2019
Modelling malaria and sickle cell gene
TLDR
The main aim is to investigate the impact of malaria treatment on the frequency of sickle cell gene, and develops a mathematical model that describes the interactions between malaria and sicklecell gene under malaria treatment.
An Immune Basis for Malaria Protection by the Sickle Cell Trait
TLDR
Analysis of the age-specific protection afforded by HbAS against clinical malaria in children living on the coast of Kenya found that protection increased with age from only 20% in the first 2 y of life to a maximum of 56% by the age of 10 y, returning thereafter to 30% in participants greater than 10 y old.
Human red blood cell polymorphisms and malaria.
  • T. Williams
  • Biology, Medicine
    Current opinion in microbiology
  • 2006
Differential impact of sickle cell trait on symptomatic and asymptomatic malaria.
TLDR
A mathematical model of malaria transmission that incorporates the evolutionary dynamics of S-gene frequency indicates that the fitness of sickle cell trait is likely to increase with the proportion of symptomatic malaria infections, and shows that control efforts aimed at diminishing the burden of symptoma malaria are not likely to eradicate malaria in endemic areas.
Sickle Cell Anaemia and Malaria
  • L. Luzzatto
  • Medicine
    Mediterranean journal of hematology and infectious diseases
  • 2012
TLDR
The close and complex relationship between this blood disease and this infectious disease is focused on, with patients who are homozygous for the sickle gene and therefore suffer from sickle cell anaemia (SCA) highly susceptible to the lethal effects of malaria.
Influence of Sickle Cell Gene on the Allelic Diversity at the msp-1 locus of Plasmodium falciparum in Adult Patients with Severe Malaria
TLDR
Sickle gene was found to reduce both the parasite densities and diversity of P. falciparum in adults with severe malaria.
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