Protective effects of the inhibition of the renin-angiotensin system against gastric mucosal lesions induced by cold-restraint in the rat.

Abstract

Experiments were designed to examine whether inhibition of the renin-angiotensin system alters gastric mucosal damage in conscious rats subjected to restraint. Two hours immobilization resulted in an ulcer index of 46 +/- 4 (n = 16) which was decreased by converting enzyme inhibitor (MK 422, enalaprilat) doses of 1 and 10 mg.kg-1.h-1 by 50 +/- 16 (n = 8… (More)

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