Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury.


BACKGROUND In the present study, we investigated the possible modulatory effect of losartan, an angiotensin receptor blocker, on oxidative stress induced by cisplatin (CDDP) as well as on CDDP uptake by the kidney. METHODS Rats were injected with a single dose of CDDP (7 mg/kg) and/or losartan (in either a single dose of 60 mg/kg or divided doses (10 mg… (More)
DOI: 10.1159/000262453


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