Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.

@article{Hofmann2009ProtectiveEO,
  title={Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.},
  author={Ulrich D W Hofmann and Natalie Burkard and Carolin Vogt and Annemarie Thoma and Stefan Frantz and Georg Ertl and Oliver Ritter and Andreas Bonz},
  journal={Cardiovascular research},
  year={2009},
  volume={83 2},
  pages={285-93}
}
AIMS Several experimental studies have demonstrated protection against cardiac ischaemia-reperfusion injury achieved by pre-treatment with exogenous sphingosine-1-phosphate (S1P). We tested the hypothesis that pharmacological S1P receptor agonists improve recovery of function when applied with reperfusion. METHODS AND RESULTS Isolated rat cardiomyocytes were stimulated with exogenous S1P, the selective S1P1 receptor agonist SEW2871, or the S1P1/3 receptor agonist FTY720. Western blot analysis… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…