Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

@article{Manczak2016ProtectiveEO,
  title={Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.},
  author={Maria Manczak and Ramesh Kandimalla and David Fry and Hiromi Sesaki and P Hemachandra Reddy},
  journal={Human molecular genetics},
  year={2016},
  volume={25 23},
  pages={
          5148-5166
        }
}
The purpose of our study was to understand the protective effects of reduced expression of dynamin-related protein (Drp1) against amyloid beta (Aβ) induced mitochondrial and synaptic toxicities in Alzheimer's disease (AD) progression and pathogenesis. Our recent molecular and biochemical studies revealed that impaired mitochondrial dynamics-increased mitochondrial fragmentation and decreased fusion-in neurons from autopsy brains of AD patients and from transgenic AD mice and neurons expressing… CONTINUE READING

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