Protective effects of quercetin and crocin in the kidneys and liver of obese Sprague-Dawley rats with Type 2 diabetes: Effects of quercetin and crocin on T2DM rats

@article{Lai2020ProtectiveEO,
  title={Protective effects of quercetin and crocin in the kidneys and liver of obese Sprague-Dawley rats with Type 2 diabetes: Effects of quercetin and crocin on T2DM rats},
  author={Linglin Lai and Hui-Qin Lu and Wen-Na Li and Hui-Ping Huang and He-Ying Zhou and Ennian Leng and Yue-yue Zhang},
  journal={Human \& Experimental Toxicology},
  year={2020},
  volume={40},
  pages={661 - 672}
}
Quercetin and crocin are the main active constituents of Eucommia and Gardenia species, respectively. This study was conducted to explore the effects of quercetin and crocin on fat reduction and renal fibrosis and the relationship of these compounds with autophagy. First, a model of high-fat diet- and streptozotocin-induced type 2 diabetes was established and then subjected model animals to 8 weeks of metformin, quercetin and crocin gavage. Then, a high glucose-induced rat mesangial cells (RMCs… 

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