Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice

@article{Wu2003ProtectiveEO,
  title={Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice},
  author={Chun-Fu Wu and Yan Li Liu and Ming-hui Song and Wen Liu and Jin Hui Wang and Xian Li and Jing Y Yang},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={76},
  pages={103-109}
}
In the present study, pseudoginsenoside-F(11) (PF(11)), a saponin that existed in American ginseng, was studied on its protective effect on methamphetamine (MA)-induced behavioral and neurochemical toxicities in mice. MA was intraperitoneally administered at the dose of 10 mg/kg four times at 2-h intervals, and PF(11) was orally administered at the doses of 4 and 8 mg/kg two times at 4-h intervals, 60 min prior to MA administration. The results showed that PF(11) did not significantly influence… 
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