Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action.

@article{Matsuda2002ProtectiveEO,
  title={Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action.},
  author={Hisashi Matsuda and Yutana Pongpiriyadacha and Toshio Morikawa and Yousuke Kashima and Kyoko Nakano and Masayuki Yoshikawa},
  journal={Bioorganic & medicinal chemistry letters},
  year={2002},
  volume={12 3},
  pages={477-82}
}
The methanolic extract from the leaves of Tasmannia lanceolata was found to potently inhibit ethanol-induced gastric lesions in rats. Through bioassay-guided separation, three known sesquiterpenes, polygodial, polygodial 12 alpha-acetal, and polygodial 12 beta-acetal, and a new sesquiterpene, methyl isodrimeninol, were isolated as the active constituents. Among them, polygodial showed very potent gastroprotective effects (ED(50)=0.028 mg/kg, po). From the gastroprotective effects of various… CONTINUE READING

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