Protective effects of pioglitazone against global cerebral ischemic-reperfusion injury in gerbils.

@article{Kaundal2009ProtectiveEO,
  title={Protective effects of pioglitazone against global cerebral ischemic-reperfusion injury in gerbils.},
  author={Ravinder K Kaundal and Seethalakshmi R Iyer and Ashutosh Kumar and Shyam Sunder Sharma},
  journal={Journal of pharmacological sciences},
  year={2009},
  volume={109 3},
  pages={361-7}
}
Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detailed preclinical evaluation in at least 2 species and multiple cerebral ischemia models to avoid the clinical failure. Considering these recommendations, in the present study, we… CONTINUE READING

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