Protective effects of phytochemical antioxidants against neurotoxin-induced degeneration of dopaminergic neurons.

Abstract

The specific toxicity to dopaminergic neurons of psychostimulants and neurotoxins has been extensively studied in vivo and in vitro, and findings have been used to establish animal models of amphetamine psychosis or Parkinson's disease. The multiple mechanisms of neurotoxicity operating in these disorders are known to involve oxidative stress or… (More)

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