Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes

@article{Mizuno2005ProtectiveEO,
  title={Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes},
  author={Tetsuya Mizuno and Reiko Kuno and Atsumi Nitta and Toshitaka Nabeshima and Guiqin Zhang and Jun Kawanokuchi and Jinyan Wang and Shijie Jin and Hideyuki Takeuchi and Akio Suzumura},
  journal={Brain Research},
  year={2005},
  volume={1066},
  pages={78-85}
}
Roles of Glia‐Derived Cytokines on Neuronal Degeneration and Regeneration
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Observations suggest that glial cell–derived cytokines may synergistically function in neuronal degeneration with other toxic factors produced by activated microglia, and that some of them may also function in regeneration by inducing neurotrophic factors.
Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
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The results suggest that the secreted proteinLCN2 is an autocrine modulator of the functional polarization of astrocytes in the presence of immune or inflammatory stimuli and that LCN2 could be targeted therapeutically to dampen proinflammatory astroCytic activation and related pathologies in the CNS.
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NT4 secretion, which was markedly induced by exposure to both AMYb and EPO in N9 murine microglias, may be an important result for neuronal survival, suggest that inflammatory mechanisms in microglia may also involve the neuroprotective response of these cells; this may be a promising area of study of neurodegenerative processes.
A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
TLDR
The tri-culture consisting of neurons, astrocytes, and microglia more faithfully mimics in vivo neuroinflammatory responses than standard mono- and co-cultures and played a significant neuroprotective role during glutamate-induced excitotoxicity.
Resveratrol promotes neurotrophic factor release from astroglia
TLDR
Overall, resveratrol is effective in promoting astroglia-derived neurotrophic factor release, and this effect is mediated, at least in part, by the activation of ERK1/2 and CREB.
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