Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes

  title={Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes},
  author={Tetsuya Mizuno and Reiko Kuno and Atsumi Nitta and Toshitaka Nabeshima and Guiqin Zhang and Jun Kawanokuchi and Jinyan Wang and Shijie Jin and Hideyuki Takeuchi and Akio Suzumura},
  journal={Brain Research},
Roles of Glia‐Derived Cytokines on Neuronal Degeneration and Regeneration
Observations suggest that glial cell–derived cytokines may synergistically function in neuronal degeneration with other toxic factors produced by activated microglia, and that some of them may also function in regeneration by inducing neurotrophic factors.
Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
The results suggest that the secreted proteinLCN2 is an autocrine modulator of the functional polarization of astrocytes in the presence of immune or inflammatory stimuli and that LCN2 could be targeted therapeutically to dampen proinflammatory astroCytic activation and related pathologies in the CNS.
The neurotoxic effect of astrocytes activated with toll-like receptor ligands
The Effect of Erythropoietin on Neurotrophic Factors in N9 Murine Microglial Cells
NT4 secretion, which was markedly induced by exposure to both AMYb and EPO in N9 murine microglias, may be an important result for neuronal survival, suggest that inflammatory mechanisms in microglia may also involve the neuroprotective response of these cells; this may be a promising area of study of neurodegenerative processes.
A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
The tri-culture consisting of neurons, astrocytes, and microglia more faithfully mimics in vivo neuroinflammatory responses than standard mono- and co-cultures and played a significant neuroprotective role during glutamate-induced excitotoxicity.
Resveratrol promotes neurotrophic factor release from astroglia
Overall, resveratrol is effective in promoting astroglia-derived neurotrophic factor release, and this effect is mediated, at least in part, by the activation of ERK1/2 and CREB.


Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.
It is demonstrated that LT possesses potent cytotoxic activity against oligodendrocytes and that the major mechanism involved in this process is DNA fragmentation.
Production of tumor necrosis factor-alpha by microglia and astrocytes in culture
Intracerebral Production of Tumor Necrosis Factor-α, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia
The local pattern of proinflammatory cytokine release was studied in Alzheimer disease (AD) and vascular dementia (VAD), by measuring intrathecal levels of IL-1β, IL-6, TNF-α, and its naturally
Macrophage colony stimulatory factor and interferon‐γ trigger distinct mechanisms for augmentation of β‐amyloid‐induced microglia‐mediated neurotoxicity
It is reported here that while both MCSF and IFNγ induce microglial‐mediated fAβ neurotoxicity, their mechanisms of toxicity differ and the neurotoxicity resulting from ROS release by fA β/MCSF coactivated microglia may be a more appropriate model for assessingfAβ‐induced microglian‐mediated neuropathology in AD.
Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro.
It is suggested that TGF-beta could be a negative regulator in the CNS cytokine network by inhibiting the function of microglia in inflammation or in immunoregulation.
Activation of microglial cells by β-amyloid protein and interferon-γ
It is suggested that Aβ and IFN-γ activate microglia to produce reactive nitrogen intermediates and TNF-α, and this may have a role in the pathogenesis of neuronal degeneration observed in ageing and Alzheimer's disease.