Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line

@article{Iwata1998ProtectiveEO,
  title={Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line},
  author={E. Iwata and I. Miyazaki and M. Asanuma and Azusa Iida and N. Ogawa},
  journal={Neuroscience Letters},
  year={1998},
  volume={251},
  pages={49-52}
}
We examined the effects of nicergoline on hydrogen peroxide (H2O2)-induced neurotoxicity in cultured rat neuronal cell line (B50). H2O2 induced death of B50 cells in a dose-dependent manner. The H2O2-induced neuronal cell death was significantly decreased in B50 cells maintained in the presence of nicergoline. We compared the levels of antioxidants (glutathione, catalase and superoxide dismutase) in nicergoline-treated and untreated B50 cells. Lipid peroxidation products (thiobarbituric acid… Expand
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