Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.

@article{Lee2002ProtectiveEO,
  title={Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo.},
  author={Yen-Mei Lee and Huey-Rue Chen and George Hsiao and Joen-Rong Sheu and Jhi-Joung Wang and Mao-Hsiung Yen},
  journal={Journal of pineal research},
  year={2002},
  volume={33 2},
  pages={
          72-80
        }
}
The production of oxygen free radicals has been strongly implicated as an important pathophysiological mechanism mediating myocardial ischemia/reperfusion (I/R) injury. Various antioxidants have cardioprotective effects. Melatonin, an indoleamine synthesized by the pineal gland, is a potent antioxidant and a direct free radical scavenger. This is the first in vivo study to evaluate the effect of melatonin (0.5, 1.0, and 5.0 mg/kg, i.v. bolus) on myocardial I/R injury in anesthetized Sprague… CONTINUE READING

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