Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation

@article{Karbownik2000ProtectiveEO,
  title={Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation},
  author={Małgorzata Karbownik and Russell J Reiter and Wenbo Qi and Joaqu{\'i}n Garc{\'i}a and Dun-xian Tan and L. Manchester and Vijayalaxmi},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={211},
  pages={137-144}
}
The aim of the study was to examine the potential protective effect of melatonin against whole body ionizing radiation (800 cGy). Changes in 8-hydroxy-2′-deoxyguanosine (8-OH-dG) levels, an index of DNA damage, and alterations in membrane fluidity (the inverse of membrane rigidity) and lipid peroxidation in microsomal membranes, as indices of damage to… CONTINUE READING