Protective effects of lysozyme chloride and reduced glutathione on betel quid chewing-produced gastric oxidative stress and haemorrhagic ulcer in rats

  title={Protective effects of lysozyme chloride and reduced glutathione on betel quid chewing-produced gastric oxidative stress and haemorrhagic ulcer in rats},
  author={C. R. Hung},
  • C. Hung
  • Published 1 May 2004
  • Medicine, Biology
  • InflammoPharmacology
The pathogenic mechanisms underlying betel quid chewing (BQC)-induced gastric haemorrhagic ulcer are totally unknown. This study first demonstrated that BQC produced gastric haemorrhagic ulcer via oxidative stress that could be protected by lysozyme chloride and glutathione in rats. Male Wistar rats were fed with regular pellet food or BQC-containing diets. After 1–90 days rats were deprived of food for 24 h. Rat stomachs were irrigated for 3 h with normal saline or simulated gastric juice… 

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