Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils

@inproceedings{Lee2010ProtectiveEO,
  title={Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils},
  author={Jen-pei Lee and Yi-ching Li and Hung-Yi Chen and Ruey-hseng Lin and Shiang-suo Huang and Hui-ling Chen and Pai-chuan Kuan and Mao-fang Liao and Chun-Jung Chen and Yu-hsiang Kuan},
  booktitle={Acta Pharmacologica Sinica},
  year={2010}
}
AbstractAim:To investigate whether luteolin, the major polyphenolic components of Lonicera japonica, has beneficial effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and to determine whether the protective mechanism involves anti-inflammatory effects on neutrophils.Methods:ALI was induced with intratracheal instillation of LPS in mice. The level of ALI was determined by measuring the cell count and protein content in bronchoalveolar lavage (BAL) fluid. Neutrophils were… CONTINUE READING

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