Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.

  title={Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.},
  author={Hong-jin Wu and Jing Hao and Shengqi Wang and Bi-Lian Jin and Xian-bing Chen},
  journal={European journal of pharmacology},
  volume={674 2-3},
To investigate the effects of Ligustrazine, a compound derived from chuanxiong, on tumor necrosis factor-α (TNF-α) stimulated endothelial cells. Human umbilical vein endothelial cells (HUVECs) were stimulated with TNF-α in vitro. Nitric oxide (NO) was measured as a standard of endothelial dysfunction. Two important indicators of autoimmunity, intracellular adhesion molecular-1 (ICAM-1) and heat shock protein 60 (HSP60), were selected to evaluate the influence of Ligustrazine on HUVECs… CONTINUE READING

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