Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: Relationship to reduced serum TNF alpha level and increased turnover of neutrophils

@article{Zimecki2004ProtectiveEO,
  title={Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: Relationship to reduced serum TNF alpha level and increased turnover of neutrophils},
  author={Michał Zimecki and Jolanta Artym and Grzegorz Chodaczek and Maja Kocięba and Marian L. Kruzel},
  journal={Inflammation Research},
  year={2004},
  volume={53},
  pages={292-2296}
}
Objective and Design:Previous studies demonstrated that lactoferrin (LF), given intravenously (i.v.), 24 h before lethal Escherichia coli (E. coli) infection, protects mice against mortality. The aim of this investigation was to determine whether downregulation of serum TNF alpha activity and increase of neutrophil number in the circulation and bone marrow by LF could contribute to the protective action of LF against E. coli-induced sepsis. Materials and subjects:CBA female mice, 10–12 week old… CONTINUE READING