Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic Escherichia coli O157:H7 infection.

@article{FloresVillaseor2012ProtectiveEO,
  title={Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic Escherichia coli O157:H7 infection.},
  author={H{\'e}ctor M. Flores-Villase{\~n}or and Adri{\'a}n Canizalez-Rom{\'a}n and Jorge Vel{\'a}zquez-Rom{\'a}n and Kamran Nazmi and Jan G. M. Bolscher and Nidia Le{\'o}n-Sicairos},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2012},
  volume={90 3},
  pages={405-11}
}
Mice orally infected with enterohaemorrhagic Escherichia coli (EHEC) O157:H7 were used to evaluate the activity of bovine lactoferrin (bLF) and the synthetic peptide LFchimera. Groups of BALB/c mice inoculated intragastrically with EHEC O157:H7 showed chronic intestinal infection with the pathogen that persisted over 6 days and resulted in a high mortality rate (90%). LFchimera and kanamycin significantly decreased (40%) this mortality rate (P = 0.028). On the other hand, although mice… CONTINUE READING

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